Related Experiment Videos
Activity of Parthenolide at 5HT2A receptors
J T Weber1, M F O'Connor, K Hayataka
1Department of Pharmaceutical Sciences, School of Pharmacy, University of Montana, Missoula 59812-1075, USA.
Journal of Natural Products
|June 1, 1997
Abstract:
Parthenolide displaces [3H]ketanserin from 5HT2A receptors from rat and rabbit brain and cloned 5HT2A receptors. Ki's are in the 100-250 microM range. These results suggest that parthenolide may be a low-affinity antagonist at 5HT receptors; it is unlikely that the entire mechanism of action can be explained by its modest 5HT2A receptor affinity.