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Uterine myomas and factors associated with hysterectomy in premenopausal women
A M Weber1, A R Mitchinson, G P Gidwani
1Department of Gynecology and Obstetrics, Cleveland Clinic Foundation, OH 44195, USA.
Objective:
Our purpose was to describe clinical characteristics in premenopausal women with uterine myomas and to identify factors associated with hysterectomy.
Study Design:
Data were collected by chart abstraction in 421 premenopausal women with myomas and analyzed by univariate and multivariable regression.
Results:
Over a median follow-up period of 29 months, 86% of women had symptoms associated with myomas and 40% had an increase in uterine size of > 2 gestational weeks. By multivariable regression, bleeding symptoms at presentation and previous surgical history of cholecystectomy and adhesiolysis were significantly associated with greater odds of hysterectomy. There was a significant interaction between age and uterine size, so that as age increased, uterine size had a greater impact on the likelihood of hysterectomy.
Conclusions:
In this cohort of premenopausal women myomas were associated with symptoms in almost all women over the follow-up period. Hysterectomy was performed in 22% of women overall.