Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Kinking deformities in collagen (author's transl)]

T Nemetschek, R Jonak, A Meinel

    Archiv Fur Orthopadische Und Unfall-Chirurgie
    |September 29, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Ultrathin catalyst-free InAs nanowires on silicon with distinct 1D sub-band transport properties.

    Nanoscale·2020
    Same author

    Tuning structure and mechanical properties of Ta-C coatings by N-alloying and vacancy population.

    Scientific reports·2018
    Same author

    Tuning Lasing Emission toward Long Wavelengths in GaAs-(In,Al)GaAs Core-Multishell Nanowires.

    Nano letters·2018
    Same author

    The importance of genetic susceptibility in Dupuytren's disease.

    Clinical genetics·2014
    Same author

    c-kit/CD 117 positive cells in the myometrium of pregnant women and those with uterine endometriosis.

    Archives of gynecology and obstetrics·2012
    Same author

    [Long-term static overnight extension splinting following percutaneous needle fasciotomy].

    Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Mikrochirurgie der Peripheren Nerven und Gefasse : Organ der V...·2011

    Stretching collagen beyond its physiological limits alters its mechanical properties and fine structure. Increased stretch and cross-link density exacerbate collagen damage, potentially linking fibril kinking to tendon rupture.

    Area of Science:

    • Biomaterials Science
    • Connective Tissue Research
    • Structural Biology

    Context:

    • Collagen fibrils are key structural proteins in connective tissues.
    • Understanding collagen's response to mechanical stress is crucial for tissue engineering and injury prevention.

    Purpose:

    • To investigate the effects of excessive tensile stretch on collagen fibril structure and properties.
    • To determine the relationship between stretch, cross-linking, and collagen deformation.

    Summary:

    • Collagen fibrils were subjected to stretch beyond physiological ranges, and their mechanical dimensions, thermostability, and fine structure were analyzed using X-ray diffraction and electron microscopy.
    • Significant alterations in tensile strength and fine structure were observed, with severity dependent on stretch magnitude and collagen cross-link density.

    Related Experiment Videos

  • Observed deformities included fibril splitting into subfibrillar units and localized kinking, with the mechanism of kinking being a focus of investigation.

    • Impact:

    • Findings elucidate the structural basis of collagen damage under mechanical overload.
    • Identifies fibrillar kinking as a potential precursor to tendon rupture.
    • Provides insights for developing strategies to prevent connective tissue injuries and improve biomaterial design.