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Oncoprotein signalling and mitosis

A D Laird1, D Shalloway

  • 1Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, NY 14853, USA.

Cellular Signalling
|May 1, 1997
PubMed
Summary
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Oncoproteins can disrupt cell cycle checkpoints, particularly in the G2 and M phases, which is crucial for cancer development. Understanding these disruptions aids in targeting cancer progression.

Area of Science:

  • Cell Biology
  • Molecular Oncology
  • Cancer Research

Background:

  • Cell cycle progression is tightly regulated by checkpoints, with a focus on G1 phase control in cancer research.
  • Transformed cells often exhibit compromised G2 and mitotic checkpoints, involving tumor suppressor proteins and oncoprotein kinases.
  • Key regulators like p53, ATM, Src family kinases, and the Ras/Raf/MAPK pathway are implicated in G2/M phase regulation.

Purpose of the Study:

  • To investigate the roles of oncoproteins in G2 and M phase cell cycle regulation.
  • To explore how disruptions in G2/M checkpoints contribute to cellular transformation.
  • To identify potential targets of oncoproteins involved in mitotic progression.

Main Methods:

  • Analysis of cell cycle checkpoint regulation in transformed cells.

Related Experiment Videos

  • Investigating the activity and targets of specific oncoproteins and kinases during G2/M phase.
  • Review of existing literature on tumor suppressor proteins and oncoprotein functions in mitosis.

    • Main Results:

    • G2 and mitotic checkpoints are frequently compromised in cancer cells.
    • Oncoprotein kinases like Src family kinases, Mos, and MAPK pathway elements are active and crucial during G2/M.
    • Potential targets include gene expression regulators (Sam68) and microtubule dynamics regulators (Oncoprotein 18/stathmin).

    Conclusions:

    • Oncoproteins play a significant role in regulating and potentially disrupting G2 and M phase progression.
    • Perturbation of G2/M checkpoints by oncoproteins is a key mechanism contributing to cellular transformation and cancer.
    • Targeting these oncoproteins and their downstream effectors may offer therapeutic strategies for cancer treatment.