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Sphincter of Oddi dysfunction is associated with chronic pancreatitis
P R Tarnasky1, B Hoffman, L Aabakken
1Medical University of South Carolina, Digestive Disease Center, Charleston, USA.
The American Journal of Gastroenterology
|July 1, 1997
Summary
Sphincter of Oddi dysfunction is linked to early chronic pancreatitis in patients with unexplained abdominal pain. This suggests dysfunction may play a role in the disease
Area of Science:
- Gastroenterology
- Pancreatology
- Biliary Medicine
Background:
- Chronic pancreatitis can stem from ductal obstruction.
- Previous sphincter of Oddi motility studies in chronic pancreatitis patients yielded inconclusive results.
Purpose of the Study:
- To investigate the association between papillary sphincter dysfunction and early chronic pancreatitis.
- To clarify the role of sphincter of Oddi dysfunction in unexplained pancreaticobiliary pain.
Main Methods:
- Sphincter of Oddi manometry was performed on 104 patients with unexplained upper abdominal pain.
- Patients were evaluated for chronic pancreatitis using pancreatic ductography, endoscopic ultrasound, and pancreatic fluid bicarbonate concentration.
Main Results:
- Patients with sphincter of Oddi dysfunction were four times more likely to exhibit evidence of chronic pancreatitis (OR=4.6, p=0.01).
- Among 68 patients with sphincter of Oddi dysfunction, 20 (29%) showed structural evidence of chronic pancreatitis.
- A significant majority (87%) of patients with chronic pancreatitis had sphincter of Oddi dysfunction.
Conclusions:
- Sphincter of Oddi dysfunction is associated with chronic pancreatitis changes in patients presenting with unexplained pancreaticobiliary pain.
- Further longitudinal studies are necessary to validate these preliminary findings.