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Amlodipine overdose

E J Stanek1, C E Nelson, D DeNofrio

  • 1Department of Pharmacy Practice Philadelphia College of Pharmacy and Science, PA 19104, USA.

The Annals of Pharmacotherapy
|July 1, 1997
PubMed
Summary
This summary is machine-generated.

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This case report details a nonfatal intentional overdose of amlodipine (a calcium channel blocker) in a 42-year-old woman. The overdose resulted in prolonged hypotension, sinus tachycardia, and transient pulmonary edema, highlighting the need for aggressive management.

Area of Science:

  • Pharmacology
  • Toxicology
  • Emergency Medicine

Background:

  • Amlodipine is a widely prescribed calcium channel blocker for hypertension.
  • Intentional overdoses, while uncommon, can lead to significant and prolonged adverse effects.

Observation:

  • A 42-year-old woman ingested 50-100 mg of amlodipine with alcohol.
  • She presented with mild symptoms, including hypotension (79/50 mm Hg) and sinus tachycardia.
  • Laboratory findings revealed elevated serum amlodipine levels (88 ng/mL) and mild metabolic acidosis.

Findings:

  • The patient developed transient pulmonary edema after fluid resuscitation.
  • Hemodynamic effects, including hypotension and tachycardia, were prolonged due to amlodipine's long elimination half-life.
  • Serum amlodipine levels remained elevated for at least 35 hours post-ingestion.

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Implications:

  • Amlodipine overdose necessitates aggressive decontamination and extended clinical monitoring.
  • Healthcare providers should be vigilant for potential complications like pulmonary edema in overdose cases.
  • This case underscores the importance of supportive care for patients with amlodipine-induced hemodynamic instability.