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Inflammatory response to calcium hydroxide based root canal sealers
L A Silva1, M R Leonardo, L H Faccioli
1Department of Pediatric Dentistry, Ribeirão Preto Dental School, University of São Paulo, Brazil.
Journal of Endodontics
|February 1, 1997
Summary
This study compared the inflammatory responses to four dental sealers in mice. Sealapex showed a less intense inflammatory reaction and localized necrosis compared to CRCS, Apexit, and Sealer 26.
Area of Science:
- Biomaterials Science
- Immunology
- Dental Materials
Background:
- Dental sealers are crucial for root canal therapy.
- Understanding their biocompatibility and inflammatory potential is essential for clinical success.
Purpose of the Study:
- To evaluate and compare the inflammatory responses induced by four root canal sealers: Sealapex, CRCS, Apexit, and Sealer 26.
- To assess the tissue reactions in both subcutaneous tissue and peritoneal cavity models in Balb/c mice.
Main Methods:
- Subcutaneous implantation of sealers in mice, with analysis at 2, 4, 8, and 16 days.
- Intraperitoneal injection of sealer solutions, with analysis at 6 and 24 hours, and 5 and 15 days.
- Histological examination focusing on inflammatory cell infiltration, differentiation, and tissue necrosis.
Main Results:
- All sealers induced initial neutrophilia in subcutaneous tissue; Sealapex showed less intense inflammation and localized necrosis.
- In the peritoneal cavity, all sealers caused polymorphonuclear leukocyte migration, with Sealer 26 and Apexit showing more intense responses initially.
- Mononucleate cell increase was observed for all sealers in the peritoneal cavity, normalizing by 15 days.
Conclusions:
- Sealapex demonstrated a more favorable inflammatory profile compared to CRCS, Apexit, and Sealer 26 in both tested models.
- The choice of root canal sealer can significantly influence the host's inflammatory and tissue response.