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[Respiratory inflammation]

S T Holgate1

  • 1Médecine Universitaire, Southampton General Hospital, Angleterre.

Allergie Et Immunologie
|March 1, 1997
PubMed
Summary
This summary is machine-generated.

Respiratory viruses, particularly rhinovirus (RV), frequently trigger asthma attacks and wheezing in children. Targeting the viral and inflammatory pathways offers a new strategy for asthma prevention.

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Area of Science:

  • Pulmonology
  • Virology
  • Immunology

Context:

  • Respiratory viruses are the primary cause of asthma exacerbations, accounting for over 80% of wheezing episodes in children.
  • Atopic individuals exhibit an increased susceptibility to respiratory viral infections, ranging from mild to severe.

Purpose:

  • To elucidate the mechanisms by which rhinovirus (RV) infections contribute to asthma exacerbations.
  • To identify potential therapeutic targets for preventing virus-induced asthma attacks.

Summary:

  • Rhinovirus (RV) colonizes the respiratory epithelium, inducing rhinitis via non-inflammatory, nerve-mediated pathways in the upper airways.
  • In the lower airways, RV infection triggers an inflammatory response involving eosinophils and cytokines like IL-8, perpetuating inflammation.

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  • This viral-inflammatory pathway presents a novel target for asthma prevention strategies.

    • Impact:

    • Understanding the distinct pathways of RV infection in the upper and lower airways is crucial.
    • Identifying the viral/inflammatory pathway provides a new avenue for developing preventative therapies for asthma.
    • This research may lead to targeted interventions to reduce the burden of virus-induced asthma attacks in susceptible populations.