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[Malignant lymphoma with epithelioid cells]

J Macák1, L Plank, I Krc

  • 1Ustav patologické anatomie LF UP, Olomouc.

Ceskoslovenska Patologie
|February 1, 1997
PubMed
Summary

Malignant lymphomas with epithelioid cells, often featuring T lymphocytes, may present diagnostic challenges. Their presence does not necessarily indicate a milder disease course or better prognosis.

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Area of Science:

  • Hematopathology
  • Oncology
  • Immunology

Context:

  • Malignant lymphomas (ML) with epithelioid cells present a complex diagnostic picture.
  • These lymphomas often exhibit a variegated cell population with a significant T lymphocyte admixture.
  • Rare Reed-Sternberg cell-like elements can also be present.

Purpose:

  • To investigate the classification and clinical behavior of malignant lymphomas characterized by epithelioid cells.
  • To clarify diagnostic ambiguities between different lymphoma subtypes, including peripheral T-cell lymphomas and B-cell lymphomas.
  • To assess the prognostic significance of epithelioid cell presence in malignant lymphomas.

Summary:

  • The study analyzed 6 cases of malignant lymphomas with epithelioid cells, alongside a control case of Hodgkin's disease.
  • Phenotyping revealed subtypes including angioimmunoblastic lymphadenopathy with dysproteinemia (AILD), centroblastic ML, T-rich B-cell lymphoma, and Hodgkin's disease.
  • Immunohistochemistry showed CD20 and CD30 positivity in some large cells, aiding classification.

Impact:

  • Highlights potential diagnostic overlaps between lymphoma subtypes, such as AILD and T-rich B-cell lymphoma.
  • Suggests that the presence of epithelioid cells in malignant lymphomas may not correlate with a favorable prognosis.
  • Underscores the importance of thorough classification and autopsy findings in understanding lymphoma behavior.

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