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Postantibiotic effect of trovafloxacin on Pseudomonas aeruginosa

F J Boswell1, J M Andrews, R Wise

  • 1Department of Medical Microbiology, City Hospital NHS Trust, Birmingham, UK.

The Journal of Antimicrobial Chemotherapy
|June 1, 1997
PubMed

Insights

Trovafloxacin demonstrated a notable postantibiotic effect (PAE) against most Pseudomonas aeruginosa strains tested. The duration of this effect increased with higher drug concentrations and longer exposure times.

Area of Science:

  • Microbiology
  • Pharmacology
  • Infectious Diseases

Background:

  • Pseudomonas aeruginosa is an opportunistic pathogen.
  • The postantibiotic effect (PAE) is a crucial pharmacokinetic/pharmacodynamic parameter.
  • Understanding PAE aids in optimizing antibiotic dosing regimens.

Purpose of the Study:

  • To evaluate the postantibiotic effect (PAE) of trovafloxacin against Pseudomonas aeruginosa.
  • To determine the influence of drug concentration and exposure time on trovafloxacin's PAE.

Main Methods:

  • Investigated the PAE of trovafloxacin (CP 99,219) using six strains of Pseudomonas aeruginosa.
  • Tested drug concentrations at 0.5, 1, 2, and 4 times the minimum inhibitory concentration (MIC).

Main Results:

  • Trovafloxacin exhibited a significant PAE in four out of six P. aeruginosa strains.
  • Observed PAE values ranged from 0.3 to 2.3 hours.
  • PAE duration increased with higher trovafloxacin concentrations and prolonged exposure.

Conclusions:

  • Trovafloxacin displays a significant postantibiotic effect against susceptible strains of P. aeruginosa.
  • The findings suggest that trovafloxacin's efficacy is concentration- and time-dependent.
  • PAE data can inform therapeutic strategies for P. aeruginosa infections.

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