Related Experiment Videos
Serum sialic acid concentration and atherosclerotic risk factors
I Wakabayashi1, K Sakamoto, S Yoshimoto
1Department of Hygiene, Hyogo College of Medicine, Japan.
Insights
Increased serum sialic acid levels are linked to key atherosclerotic cardiovascular disease risk factors. This suggests sialic acid may indicate the progression of atherosclerosis, particularly inflammation processes.
Area of Science:
- Biochemistry
- Cardiovascular Medicine
- Clinical Chemistry
Background:
- Atherosclerotic cardiovascular disease (ASCVD) poses a significant global health burden.
- Elevated serum sialic acid has been observed in conditions associated with ASCVD, but its precise role remains unclear.
Purpose of the Study:
- To investigate the relationship between serum sialic acid levels and established atherosclerotic risk factors.
- To determine if serum sialic acid can serve as a marker for the progression of atherosclerosis.
Main Methods:
- Simple and multiple regression analyses were employed.
- Serum sialic acid levels were correlated with serum uric acid, fasting blood glucose, blood pressure, atherogenic index, and white blood cell count.
Main Results:
- Serum sialic acid showed significant correlations with multiple atherosclerotic risk factors.
- Higher serum sialic acid levels were observed with increasing quartiles of serum uric acid and fasting blood glucose.
- A positive trend was noted between serum sialic acid and quartiles of blood pressure, atherogenic index, and white blood cell count.
Conclusions:
- Serum sialic acid levels are significantly associated with various atherosclerotic risk factors.
- The findings suggest serum sialic acid may reflect the extent of atherosclerotic progression, potentially involving inflammatory processes.
Abstract:
To clarify the significance of increased blood sialic acid in atherosclerotic cardiovascular disease, we investigated the relationship between serum sialic acid level and atherosclerotic risk factors such as serum uric acid, fasting blood glucose, systolic and diastolic blood pressure, atherogenic index, and white blood cell count. By simple regression analysis, the serum sialic acid level was found to correlate significantly with these parameters. The mean sialic acid level was significantly higher in the highest quartile for serum uric acid than in its lowest quartile and also for fasting blood glucose concentration in comparison with its other three quartiles. A tendency was noted for the mean serum sialic acid level of each quartile to become higher with an increase in the quartiles of systolic or diastolic blood pressure, atherogenic index, and white blood cell count. Multiple regression analysis showed the correlations to be significant for the relationship of serum sialic acid to atherogenic index, mean arterial pressure and white blood cell count. From these results and previous findings of higher serum sialic acid levels in smokers, patients with diabetic angiopathies, and patients with hyperlipidemia, it is suggested that serum sialic acid reflects the degree of atherosclerotic progress involving inflammation processes.