Maturation of the mammalian dorsal root entry zone--from entry to no entry

Interfaces between glial cell precursors of the PNS and CNS are established early in development and form the sites where sensory axons enter and motor axons exit the developing CNS. The molecular and cellular interactions that lead to the formation of these glial interfaces are only now becoming apparent. New in-vitro techniques are providing clues as to how the maturation of PNS-CNS glial interfaces generates barriers to regenerating axons.