Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bone morphogenetic proteins in the nervous system

M F Mehler1, P C Mabie, D Zhang

  • 1Dept of Neurology and Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Trends in Neurosciences
|July 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intravitreal injection of plasminogen kringle 5, an endogenous angiogenic inhibitor, arrests retinal neovascularization in rats.

Diabetologia·2001
Same author

[Inhibition of HBV gene expression by antisense oligonucleotides using galactosylated poly (L-lysine) as a hepatotropic carrier].

Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology·2001
Same author

[Chemical characteristics of fresh snow in Mount Everest Region].

Huan jing ke xue= Huanjing kexue·2001
Same author

[Comparison of specific immune responses to duck hepatitis B virus in infected, immune, and uninfected ducks].

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology·2001
Same author

[Influence of electroporation on the biological activities of primary rat hepatocytes].

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology·2001
Same author

Association of provider and patient characteristics with HIV-infected women's antiretroviral therapy regimen.

Journal of acquired immune deficiency syndromes (1999)·2001
Same journal

Building neuroscience capacity in low- and middle-income countries: Lessons from Ghana.

Trends in neurosciences·2026
Same journal

Emulating the periodic table: A unified list of CNS terms and abbreviations for humans and experimental animals.

Trends in neurosciences·2026
Same journal

From chromatin dynamics to brain disease: Polycomb-Trithorax mechanisms in neurodevelopment.

Trends in neurosciences·2026
Same journal

Striatum regulates the cortex via the basal forebrain cholinergic system: A role for substance P.

Trends in neurosciences·2026
Same journal

A large brain adds new types of neurons: Molecular and functional signatures of spindle neurons in the human neocortex.

Trends in neurosciences·2026
Same journal

Exercise as a regulator of glymphatic function.

Trends in neurosciences·2026
See all related articles

Bone morphogenetic proteins (BMPs) are crucial for neural development, influencing cell differentiation and survival. These transforming growth factor superfamily members exhibit diverse, context-specific roles in both the central and peripheral nervous systems.

Area of Science:

  • Developmental Biology
  • Neuroscience
  • Molecular Biology

Background:

  • Bone morphogenetic proteins (BMPs) are part of the transforming growth factor superfamily.
  • BMP ligands and receptors are found in the embryonic brain and neural crest cells.

Purpose of the Study:

  • To investigate the multifaceted roles of BMPs in neural development.
  • To understand BMPs' context-specific effects on cell differentiation, survival, and apoptosis.

Main Methods:

  • The study reviews existing literature on BMP signaling during neural development.
  • Analysis of BMP expression patterns and functional outcomes in various neural contexts.

Main Results:

  • BMPs regulate neuroectoderm formation, neuronal differentiation in the peripheral nervous system, and astroglial lineage in the CNS.

Related Experiment Videos

  • BMPs also promote neuronal survival and induce apoptosis in specific neural crest populations.

    • Conclusions:

    • BMPs exhibit a wide array of context-dependent cellular effects throughout neural development.
    • These findings highlight the versatility of BMPs as signaling molecules in the nervous system.