Related Experiment Video
Updated: Aug 18, 2026

High-resolution Functional Magnetic Resonance Imaging Methods for Human Midbrain
Published on: May 10, 2012
Neurofibrillary pathology in the human paraventricular and supraoptic nuclei
C Schultz1, E Ghebremedhin, H Braak
1Department of Morphology, Johann Wolfgang Goethe University, Frankfurt/Main, Germany. Schultz@em.uni-frankfurt.de
Abstract:
Severe neurofibrillary changes were identified in the paraventricular and supraoptic nuclei of elderly individuals using markers for Alzheimer's disease-related intraneuronal pathology. This neurofibrillary pathology is remarkable in that the magnocellular paraventricular and supraoptic nuclei are particularly resistant to Alzheimer's disease. Moreover, the changes were observed even in non-demented controls, indicating that they develop independently of Alzheimer's disease. The alterations in the paraventricular and supraoptic nuclei were consistently accompanied by neurofibrillary changes in the mediobasal hypothalamus.
Related Concept Videos
Neural Regulation
Amyloid Fibrils
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...
Diencephalon: Hypothalamus and Coordination
The hypothalamus interacts with other brain regions, including the pituitary gland, through a direct physical connection called the hypothalamic-pituitary axis. The hypothalamus receives somatic and visceral inputs and...
The Pituitary Gland
Alzheimer Disease ll: Pathophysiology
Parkinson Disease ll: Pathophysiology

