Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Concomitant antitumor resistance]

R A Ruggiero1, P D Di Gianni, M Franco

  • 1Instituto de Investigaciones Hematológicas, Academia Nacional de Medicina, Buenos Aires, Argentina.

Medicina
|January 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fresh Carrier for an Old Topical Local Anesthetic: Benzocaine in Nanostructured Lipid Carriers.

ACS biomaterials science & engineering·2024
Same author

Evaluating the effects of preoperative treatment with 5-alpha reductase inhibitors in holmium laser enucleation of the prostate.

Actas urologicas espanolas·2023
Same author

Social and ideological determinants of COVID-19 vaccination status in Spain.

Public health·2023
Same author

Thyroid dysfunction in COVID-19 patients.

Journal of endocrinological investigation·2021
Same author

Attenuation of insecticide impact by a small wetland in a stream draining a horticultural basin in Argentina.

The Science of the total environment·2021
Same author

The impact of heat waves on daily mortality in districts in Madrid: The effect of sociodemographic factors.

Environmental research·2020
Same journal

Detection of VIM-3 in oral squamous cell carcinomas: methodological limitations.

Medicina·2026
Same journal

The importance of specific antibodies in VIM-3 research: addressing a key methodological flaw.

Medicina·2026
Same journal

[From the right to be cared for to the duty to care: Legal bases for the implementation of palliative care in Argentina].

Medicina·2026
Same journal

[Surrogacy].

Medicina·2026
Same journal

[The misunderstandings in interpreting the "diagnostic superiority of Artificial Intelligence" and the explainable Artificial Intelligence].

Medicina·2026
Same journal

[Artificial intelligence in medicine: between algorithmic opacity and clinical responsibility].

Medicina·2026
See all related articles

Tumor resistance in mice shows two peaks: one linked to small, immunogenic tumors and T cells, the other to large tumors and a serum factor inhibiting tumor growth. Most tumors showed resistance, with fewer metastases correlating to this resistance.

Area of Science:

  • Immunology
  • Oncology
  • Biochemistry

Context:

  • Investigating concomitant tumor resistance in mice against secondary tumor challenges.
  • Utilizing 17 tumors with varying immunogenicity in both euthymic and athymic models.
  • Examining the role of T cell-dependent and independent mechanisms in tumor resistance.

Purpose:

  • To characterize the temporal dynamics and mechanisms of concomitant tumor resistance.
  • To identify factors associated with tumor resistance and the absence of metastases.
  • To partially characterize a novel serum-based inhibitory factor.

Summary:

  • Two distinct peaks of concomitant resistance were observed during tumor development.
  • The first peak, associated with small immunogenic tumors, is T cell-dependent.

Related Experiment Videos

  • The second peak, linked to large tumors, involves a non-tumor-specific serum factor inhibiting tumor cell proliferation and correlates with reduced lung metastases.

    • Impact:

    • Identified a correlation between strong concomitant resistance, absence of lung metastases, and the presence of a serum inhibitory factor.
    • Partially characterized the inhibitory serum factor, noting its resistance to heat and pH changes, molecular weight, and spectral properties.
    • Suggests potential therapeutic implications of the serum inhibitory factor in preventing tumor metastasis.