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Occupational allergy in saffron workers

F Feo1, J Martinez, A Martinez

  • 1Allergy Division, Hospital Complex, Ciudad Real, Spain.

Allergy
|June 1, 1997
PubMed
Summary
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Saffron flower exposure can cause occupational allergies in workers, with pollen and stamens identified as key allergens. This study highlights the clinical significance and cross-reactivity of saffron allergens.

Area of Science:

  • Allergology
  • Occupational Health
  • Plant Science

Background:

  • Saffron (Crocus sativus) is commercially grown in Spain.
  • Occupational exposure to saffron may lead to sensitization.
  • Clinical significance of saffron as an occupational allergen is not well-defined.

Purpose of the Study:

  • To investigate saffron sensitization in workers.
  • To identify clinical manifestations of saffron allergy.
  • To characterize saffron allergens and evaluate cross-reactivity.

Main Methods:

  • Prick tests, Radioallergosorbent tests (RAST), and provocation tests were performed.
  • SDS-PAGE immunoblotting and gel filtration chromatography were used for allergen characterization.
  • RAST inhibition assays assessed cross-reactivity with other pollens.

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Main Results:

  • Three out of 50 saffron workers showed sensitization to saffron pollen and stamen.
  • One worker developed asthma, and two had rhinoconjunctivitis, confirmed by provocation tests.
  • A 15.5 kDa profilin allergen was identified in pollen and stamens; pistils were non-allergenic.
  • Significant cross-reactivity was observed between saffron and Lolium, Salsola, and Olea pollens.

Conclusions:

  • Saffron pollen and stamens contain allergens responsible for occupational sensitization.
  • Profilin is a key allergen in saffron, implicated in cross-reactivity.
  • Awareness of saffron allergy is crucial for occupational health in agricultural settings.