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Micromachined analytical devices: microchips for semen testing

L J Kricka1, I Faro, S Heyner

  • 1Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia 19104, USA. larry_kricka@path1a.med.upenn.edu

Journal of Pharmaceutical and Biomedical Analysis
|June 1, 1997
PubMed
Summary

Disposable glass microchips offer a feasible method for sperm motility testing. This novel approach correlates well with conventional Makler chamber analysis, showing potential for evaluating other motile cells.

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Area of Science:

  • Biomedical Engineering
  • Reproductive Biology
  • Clinical Diagnostics

Background:

  • Micromachined devices (microchips) are increasingly utilized for clinical assays.
  • Accurate assessment of sperm motility is crucial for reproductive health evaluations.

Purpose of the Study:

  • To compare sperm motility measurements obtained using disposable glass microchips versus a conventional Makler chamber.
  • To evaluate the feasibility of microchips for sperm motility testing.

Main Methods:

  • Glass microchips with microchannels were designed and fabricated.
  • Semen samples were analyzed using both microchips and a Makler chamber.
  • Sperm swimming times in microchannels were recorded and correlated with forward progression scores.

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Main Results:

  • Sperm motility determined by microchip swimming time correlated with conventional Makler chamber forward progression scores.
  • The microchip method demonstrated feasibility across a range of sperm counts and motility levels.
  • Observed swimming times in microchips ranged from 360 s to 770 s.

Conclusions:

  • Disposable glass microchips are a viable tool for sperm motility testing.
  • Microchip technology shows promise for the analysis of various motile cell types.
  • This technique offers a potential advancement in clinical diagnostic assays for reproductive medicine.