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Laser-capture Microdissection of Human Prostatic Epithelium for RNA Analysis

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Published on: November 26, 2015

Epitestosterone in human blood and prostatic tissue

L Stárka¹, R Hampl, M Hill

¹Institute of Endocrinology, Praha, The Czech Republic.

European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies

|June 1, 1997

Summary

Epitestosterone levels are similar or higher than testosterone in pre-pubertal boys, suggesting a regulatory role in androgen-dependent events. In adults, epitestosterone is significantly lower than testosterone.

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Area of Science:

Endocrinology
Andrology
Steroid Biochemistry

Background:

Epitestosterone is a C19-steroid with known anti-androgenic properties.
Its role in androgen-dependent physiological processes requires further elucidation.

Purpose of the Study:

To quantify epitestosterone levels in plasma across a wide age range of males.
To determine epitestosterone concentrations in human prostate tissue.
To assess the potential regulatory role of epitestosterone in androgen-dependent events.

Main Methods:

Plasma samples from 234 boys and men (ages 6-86) were analyzed.
Prostate tissue samples from 15 men (ages 55-82) were analyzed.
Steroid concentrations were measured using established biochemical assays.

Main Results:

Pre-pubertal boys exhibited epitestosterone levels similar to or exceeding testosterone.
Adults showed epitestosterone concentrations approximately ten times lower than testosterone.
In hyperplastic prostate tissue, epitestosterone levels were comparable to androstenedione, higher than testosterone, and lower than dihydrotestosterone.

Conclusions:

Epitestosterone may function as a regulatory factor in androgen-dependent events, particularly in pre-pubertal boys.
The findings suggest a distinct role for epitestosterone in prostate tissue compared to circulating levels in adulthood.