[Severe streptococcal complications in varicella]
M C Héraud1, Y Loriette, A Grassano
1Unité de réanimation et des maladies respiratoires, CHRU de Clermont-Ferrand, Hôtel-Dieu, France.
Insights
Group A beta-hemolytic streptococcal (GABHS) infections are increasingly seen with varicella in children. Early recognition of GABHS complications like septic shock and cellulitis in febrile children with varicella is crucial.
Area of Science:
- Pediatrics
- Infectious Diseases
- Microbiology
Background:
- Recent reports indicate a rise in group A beta-hemolytic streptococcal (GABHS) infections among children.
- A frequent association between GABHS infections and varicella (chickenpox) has been observed.
Observation:
- Two pediatric cases illustrate severe GABHS complications following varicella.
- Case 1: A 3-year-old developed septic shock and osteomyelitis due to GABHS after varicella.
- Case 2: A 4.5-year-old presented with cellulitis and adenitis, with both Staphylococcus aureus and GABHS identified.
Findings:
- GABHS infections can manifest as severe conditions like septic shock, osteomyelitis, and cellulitis in children with varicella.
- Early and appropriate antibiotic therapy is essential for managing these invasive streptococcal infections.
- Varicella can serve as a portal for secondary bacterial infections, particularly GABHS.
Implications:
- Clinicians should maintain a high index of suspicion for GABHS infections in children with varicella who present with persistent fever or unusual symptoms.
- Increased vigilance for GABHS complications is necessary in pediatric varicella cases.
- Prompt diagnosis and management of GABHS infections associated with varicella can improve patient outcomes and prevent severe sequelae.
Background:
An increase in the incidence of group A beta hemolytic streptococcal (GABHS) infections in children has been recently noted with a frequent association with varicella.
Case Reports:
Two children, 3 and 4.5 years old, developed varicella. The first one was febrile and presented a phlyctene on his left foot. Few hours after his admission, he presented a septic shock; GABHS was isolated from blood. Despite immediate adapted antibiotherapy, he developed a right tibial osteomyelitis with abscess. The second child also developed varicella and was hospitalized because of fever, bad general condition, right cervical adenitis and edema on the left wrist. Edema rapidly extended to the hand and upper arm. One purulent lesion was noted on the upper arm from whom Staphylococcus aureus and GABHS were isolated. Blood samples were sterile. The clinical course was favorable with adapted antibiotherapy. A cutaneous desquamation was observed on the 9th day and we concluded that it was a GABHS cellulitis.
Conclusion:
These two cases confirm the recent report of increase in GABHS infections associated with varicella. Such complications must be looked for in patients with varicella remaining abnormally febrile and/or presenting unusual manifestations.
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