A case of acute myelomonocytic leukaemia associated with therapy: Feulgen-DNA microdensitometric determinations

A cytochemical study of a case of acute myelomonocytic leukaemia, which arose after radiation therapy and polychemotherapy for Hodgkin's disease, is presented. The distribution of the DNA content of the circulating blood cells appears to be different from the unimodal diploid distribution reported in the literature for acute myelomonocytic leukamias not associated with therapy. This finding seems to strengthen the hypothesis, already put forward by Marinone et al. (1979), that a particular pattern of DNA content distribution could be characteristic of leukaemias linked to chemotherapy and radiotherapy.