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Brainstem respiratory networks and cough

R Shannon1, D M Baekey, K F Morris

  • 1University of South Florida, Tampa 33612, USA.

Pulmonary Pharmacology
|October 1, 1996
PubMed
Summary

This review supports a model where the medullary neuronal network, including Bötzinger/rostral ventral respiratory group (BOT/rVRG) neurons, generates cough motor patterns. These same neurons also control normal breathing (eupnoea), refuting a separate cough center.

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Area of Science:

  • Neuroscience
  • Respiratory Physiology

Background:

  • The neural control of breathing involves complex medullary networks.
  • Understanding the generation of cough motor patterns is crucial for respiratory control research.

Purpose of the Study:

  • To review evidence supporting a medullary neuronal network model for cough generation.
  • To investigate the role of Bötzinger/rostral ventral respiratory group (BOT/rVRG) neurons in cough and eupneic breathing.

Main Methods:

  • Review of existing studies on medullary neuronal networks in cats.
  • Analysis of neuronal discharge patterns during fictive cough.
  • Comparison of observed neuron behaviors with cough model simulations.

Main Results:

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  • Evidence supports bulbospinal drive to respiratory motoneurons during cough originating from medullary neurons active during eupnea.
  • BOT/rVRG neurons implicated in eupneic breathing are also involved in generating the central cough motor pattern.
  • Observed neuronal alterations during fictive cough align with network model predictions, suggesting no separate cough center.

    • Conclusions:

    • The BOT/rVRG network is central to generating the cough motor pattern.
    • A preliminary model for cough generation by the BOT/rVRG network is proposed based on observed neuron behaviors and inferred synaptic actions.