Related Experiment Video
Updated: Aug 12, 2026

Mouse- and Human-derived Primary Gastric Epithelial Monolayer Culture for the Study of Regeneration
Published on: May 7, 2018
[Reparative characteristics of gastric and duodenal mucosa in ulcer]
L P Miagkova1, O A Sklianskaia, T L Lapina
1Department of Internal Diseases Propedeutics, MMA of IM Sechenov.
Abstract:
Mucosal repair in the stomach and duodenum was assessed clinically and morphologically in various ulcer phases in 475 patients with gastroduodenal ulcer. It was found that poorly scarring ulcers are characterized by severe impairment of regeneration with epithelial proliferation prevailing over its differentiation. Participation of immune system, primarily T-cell component, in regeneration regulation is shown. Helicobacter pylori is not involved in repair. Superoxide dismutase activity in red cells and ulcer edges mucosa is prognostically significant indicating the disease phase, completeness of ulcer process.
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