Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multiple simultaneous synthesis of phenolic libraries

H V Meyers1, G J Dilley, T L Durgin

  • 1Sphinx Pharmaceuticals, Division of Eli Lilly & Co., Cambridge, MA 02139, USA.

Molecular Diversity
|September 1, 1995
PubMed
Summary

Researchers developed a cost-effective method to synthesize over 600 unique small molecules. This approach generates diverse, non-peptidyl compounds suitable for biological screening and drug discovery efforts.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Caveolin expression and localization in human keratinocytes suggest a role in lamellar granule biogenesis.

The Journal of investigative dermatology·2003
Same author

Evaluation of fan-pattern spray nozzle wear using scanning electron microscopy.

Scanning·2003
Same author

[Study on apoE gene polymorphism in Chinese type II b hyperlipidemia].

Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao·2003
Same author

Active control of acoustic reflection, absorption, and transmission using thin panel speakers.

The Journal of the Acoustical Society of America·2003
Same author

[The study on edge detection method of medical color image].

Zhongguo yi liao qi xie za zhi = Chinese journal of medical instrumentation·2003
Same author

[The observation of proliferative cell nuclear antigen and AgNORs in ocular adnexal lymphoid hyperplasia].

Yan ke xue bao = Eye science·2003

Area of Science:

  • Medicinal Chemistry
  • Organic Synthesis
  • Chemical Biology

Background:

  • The synthesis of diverse small molecule libraries is crucial for drug discovery.
  • Traditional methods for generating non-peptidyl compound diversity can be complex and costly.

Purpose of the Study:

  • To develop a facile and economical approach for synthesizing a large number of unique, non-peptidyl compounds.
  • To create a library of phenolic compounds suitable for biological screening.

Main Methods:

  • Synthesis of analogous arrays of small, non-peptidyl compounds on polystyrene resin.
  • Utilizing a functionally differentiated phenolic scaffold for batch preparation of benzamide and urea resins.
  • Derivatization in modified 96-well plates.
  • Cleavage of the phenyl benzoate link to isolate phenolic compounds.

Related Experiment Videos

Main Results:

  • Successful synthesis of over 600 unique phenolic compounds in milligram quantities.
  • Demonstration of a facile and economical method for generating non-peptidyl chemical diversity.
  • Compounds obtained were suitable for direct biological screening.

Conclusions:

  • The described technology offers an efficient and cost-effective route to diverse non-peptidyl compound libraries.
  • This approach facilitates the generation of chemical matter for biological screening and potential therapeutic development.