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Dysfunctional uterine bleeding

E Deligeoroglou1

  • 11st Department of Obstetrics and Gynecology, University of Athens, Alexandra Maternity Hospital, Greece.

Annals of the New York Academy of Sciences
|June 17, 1997
PubMed
Summary
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Dysfunctional uterine bleeding (DUB) in adolescents is often due to immature hormonal regulation, causing irregular cycles. Effective medical treatments are available to manage bleeding and prevent recurrence.

Area of Science:

  • Gynecology
  • Pediatric Endocrinology

Background:

  • Dysfunctional uterine bleeding (DUB) is a common gynecological issue in adolescents.
  • It frequently leads to emergency hospital admissions during this life stage.
  • Most cases (95%) stem from delayed maturation of the hypothalamic-pituitary-ovarian (HPO) axis, resulting in anovulatory cycles.

Purpose of the Study:

  • To outline the evaluation and management of DUB in adolescents.
  • To highlight the underlying pathophysiology of DUB in this age group.
  • To emphasize effective treatment strategies and follow-up care.

Main Methods:

  • Initial evaluation involves detailed clinical history and physical examination.
  • Laboratory tests include coagulation profile, complete blood count, and pregnancy tests.

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  • Treatment is tailored to symptom severity, focusing on hemostasis and recurrence prevention.

    • Main Results:

    • The primary cause is estrogen-induced endometrial stimulation due to lack of positive feedback on LH, leading to anovulatory cycles.
    • Modern hormonal and medical therapies offer effective DUB management.
    • Surgical interventions like dilatation and curettage are seldom necessary for adolescents.

    Conclusions:

    • DUB in adolescents is primarily linked to HPO axis immaturity.
    • Medical management is highly effective for controlling bleeding and preventing recurrence.
    • Consistent follow-up is crucial until menstrual cycles stabilize.