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Updated: Aug 11, 2026

Isolation and Culture of Neural Crest Stem Cells from Human Hair Follicles
07:00

Isolation and Culture of Neural Crest Stem Cells from Human Hair Follicles

Published on: April 6, 2013

Whole hair follicle culture

M P Philpott1, D A Sanders, T Kealey

  • 1Department of Clinical Biochemistry, University of Cambridge, Addenbrookes Hospital, United Kingdom.

Dermatologic Clinics
|October 1, 1996
PubMed

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A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...