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Related Experiment Videos

Patient-controlled sedation using propofol during interventional neuroradiologic procedures

I A Herrick1, A W Gelb, P S Tseng

  • 1Department of Anaesthesia, University Hospital, University of Western Ontario, London, Canada.

Journal of Neurosurgical Anesthesiology
|July 1, 1997
PubMed
Summary

Patient-controlled sedation (PCS) with propofol is a safe and effective option for interventional neuroradiology procedures. It provides comparable sedation and anxiolysis to midazolam-fentanyl, with similar patient satisfaction and complication rates.

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Area of Science:

  • Anesthesiology
  • Neuroradiology
  • Sedation Techniques

Background:

  • Patient-controlled sedation (PCS) with propofol is recognized for its safety and efficacy in various procedures.
  • Its application in interventional neuroradiology (INR) under regional or local anesthesia requires further evaluation.

Purpose of the Study:

  • To compare the efficacy and safety of propofol PCS versus anesthesiologist-administered midazolam-fentanyl sedation during INR procedures.

Main Methods:

  • A prospective, randomized study involving 19 patients undergoing 24 INR procedures.
  • Patients received either propofol PCS (0.5 mg/kg dose, 3-min lockout) or midazolam-fentanyl sedation.
  • Evaluated parameters included visual analogue scores (VAS) for discomfort, sedation, and anxiety, cognitive function, patient satisfaction, and complications.

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Main Results:

  • No significant differences were observed between propofol PCS and midazolam-fentanyl in sedation or anxiolysis levels.
  • Cognitive function and patient satisfaction were comparable in both groups.
  • Similar complication rates were noted, including ventilatory depression and excessive sedation in both groups. Restlessness occurred in three patients receiving propofol.

Conclusions:

  • Propofol PCS presents a safe and effective sedation method for INR procedures.
  • Its sedation and anxiolysis profile is comparable to traditional midazolam-fentanyl sedation.