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[Blepharospasm: treatment with botulinum toxin]

E R Barbosa1, H C Silva, M S Haddad

  • 1Clínica Neurológica do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo.

Revista Do Hospital Das Clinicas
|November 1, 1996
PubMed
Summary

Botulinum toxin type A injections effectively treat blepharospasm, a focal dystonia. This study found significant symptom improvement in patients unresponsive to conventional therapies, with sustained effects for approximately 90 days.

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Area of Science:

  • Neurology
  • Ophthalmology

Background:

  • Blepharospasm is a focal dystonia causing involuntary orbicularis oculi muscle contractions.
  • Conventional therapies often yield suboptimal results for blepharospasm patients.

Purpose of the Study:

  • To evaluate the efficacy and safety of botulinum toxin type A injections for treating blepharospasm.
  • To assess the response duration and side effects of this treatment modality.

Main Methods:

  • Fourteen patients (6 male, 8 female) with blepharospasm received botulinum toxin type A injections.
  • Patients had previously undergone conventional treatments with limited success.
  • Response latency, maximum effect, duration of response, and side effects were recorded.

Main Results:

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  • All 14 patients showed a good response to botulinum toxin type A.
  • The average latent period for treatment effect was 3 days, with maximum effect observed by day 16.
  • The mean duration of maximum response was 90 days.
  • Reported side effects included ptosis and lagophthalmos.

Conclusions:

  • Botulinum toxin type A is an effective treatment for blepharospasm, even in patients refractory to other therapies.
  • The treatment offers a significant duration of symptom relief.
  • Ptosis and lagophthalmos are the primary side effects to monitor.