Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Elevated homocyst(e)ine levels with preeclampsia

A Rajkovic1, P M Catalano, M R Malinow

  • 1Department of Obstetrics and Gynecology, Case Western Reserve University, Metrohealth Medical Center, Cleveland, Ohio, USA.

Obstetrics and Gynecology
|August 1, 1997
PubMed
Summary

Elevated plasma homocyst(e)ine levels were observed in nulliparous pregnant women diagnosed with preeclampsia. This finding suggests a potential link between homocyst(e)ine and preeclampsia development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Targeted whole exome sequencing and Drosophila modelling to unveil the molecular basis of primary ovarian insufficiency.

Human reproduction (Oxford, England)·2021
Same author

Rationale and study design for lifestyle intervention in preparation for pregnancy (LIPP): A randomized controlled trial.

Contemporary clinical trials·2020
Same author

A novel homozygous frame-shift variant in the LHCGR gene is associated with primary ovarian insufficiency in a Pakistani family.

Clinical genetics·2018
Same author

Associations of neonatal adiponectin and leptin with growth and body composition in African American infants.

Pediatric obesity·2018
Same author

Novel inactivating mutations of the DCAF17 gene in American and Turkish families cause male infertility and female subfertility in the mouse model.

Clinical genetics·2017
Same author

Variations in resting energy expenditure: impact on gestational weight gain.

American journal of obstetrics and gynecology·2017

Area of Science:

  • Obstetrics and Gynecology
  • Cardiovascular Research
  • Nutritional Science

Background:

  • Preeclampsia is a serious pregnancy complication.
  • Endothelial dysfunction and premature vascular disease are associated with elevated homocyst(e)ine.
  • Homocyst(e)ine is a potential risk factor in vascular pathologies.

Purpose of the Study:

  • To investigate elevated homocyst(e)ine levels in nulliparous pregnant women with preeclampsia.
  • To assess the association between homocyst(e)ine and preeclampsia in nulliparous women.

Main Methods:

  • Plasma homocyst(e)ine, folic acid, and vitamin B12 levels were measured.
  • Study included 40 nulliparous women, with 20 having preeclampsia and 20 serving as controls.
  • Measurements were taken at the time of delivery.

Related Experiment Videos

Main Results:

  • Significantly higher plasma homocyst(e)ine levels were found in women with preeclampsia (8.66 +/- 3.05 mumol/L) compared to controls (4.99 +/- 1.11 mumol/L).
  • No significant differences in folic acid or vitamin B12 levels were observed between the groups.
  • P-value < .001 indicated statistical significance for homocyst(e)ine levels.

Conclusions:

  • Plasma homocyst(e)ine is elevated in nulliparous women with preeclampsia at delivery.
  • Further research is needed to elucidate the role of homocyst(e)ine in the etiology of preeclampsia.
  • Homocyst(e)ine may be a contributing factor to preeclampsia development.