Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Apoptosis and carcinogenesis

A H Wyllie1

  • 1Sir Alastair Currie CRC Laboratories, Department of Pathology, University of Edinburgh, United Kingdom.

European Journal of Cell Biology
|July 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Death and the cell.

Immunology today·2014
Same author

New insights into the role of PML in tumour suppression.

Cell research·2008
Same author

Evidence for the receipt of DNA damage stimuli by PML nuclear domains.

The Journal of pathology·2007
Same author

Accuracy of reporting of family history of colorectal cancer.

Gut·2004
Same author

Proliferation and death of conditionally immortalized neural cells from murine neocortex: p53 alters the ability of neuron-like cells to re-enter the cell cycle.

Brain research·2003
Same author

Early-onset colorectal cancer with stable microsatellite DNA and near-diploid chromosomes.

Oncogene·2001
Same journal

Epigenetic regulation of non-apoptotic regulated cell death.

European journal of cell biology·2026
Same journal

Corrigendum to "Insulin receptor-inspired soluble insulin binder" [Eur. J. Cell Biol. 102 (2023) 151293].

European journal of cell biology·2026
Same journal

Fucosylation in cancer and its role in anti-tumor immunity.

European journal of cell biology·2026
Same journal

Ethanol stress-induced vacuole unlobing is mediated via downregulation of phosphatidylinositol-3,5-bisphosphate and Atg18 phospho-regulation.

European journal of cell biology·2026
Same journal

Letter to the Editor: TGF-β drives pulmonary fibrosis through dual dysregulation of TNF pathway transcription and splicing.

European journal of cell biology·2026
Same journal

A new photochromic sterol controls TRPC3 activity by actuating a hub of regulatory lipid coordination.

European journal of cell biology·2026
See all related articles

Apoptosis, or programmed cell death, is regulated by caspases. Defective apoptosis may lead to the persistence of damaged, mutated cancer cells, a process that appears tissue-specific.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • Apoptosis, or programmed cell death, is a fundamental biological process.
  • Its dysregulation is implicated in various diseases, including cancer.
  • Understanding apoptosis regulation is crucial for therapeutic development.

Purpose of the Study:

  • To summarize the current understanding of apoptosis and its regulation.
  • To highlight the specific role of apoptosis in cancer.
  • To explore the mechanisms linking defective apoptosis to cancer development.

Main Methods:

  • Review of existing literature on apoptosis and cancer.
  • Analysis of biochemical pathways and effector mechanisms.
  • Identification of signaling molecules and regulatory proteins.

Related Experiment Videos

Main Results:

  • Apoptosis involves the activation of cysteine proteases (caspases) that cleave cellular substrates.
  • Caspase activation is triggered by diverse stimuli, including DNA damage and cytokine signaling.
  • The bcl-2 family of proteins regulates caspase activation.
  • Defective apoptosis can lead to the accumulation of damaged cells, contributing to cancer.

Conclusions:

  • Apoptosis is a tightly regulated process involving caspases and influenced by various signaling pathways.
  • Defects in apoptosis are a significant factor in cancer development, potentially allowing mutated cells to survive.
  • Tissue-specific conditions may influence the relationship between apoptosis and cancer.