Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Primary hyperoxaluria type 2

M J Kemper1, S Conrad, D E Müller-Wiefel

  • 1Department of Urology, University Hospital Eppendorf, Hamburg, Germany.

European Journal of Pediatrics
|July 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

3D-printed digital pneumatic logic for the control of soft robotic actuators.

Science robotics·2024
Same author

The impact of marker selection, in-line near-infrared spectroscopy (NIR), and feed mix time on the coefficient of variation (mix uniformity), body weight uniformity and broiler growth performance during the starter, grower, and finisher periods.

Poultry science·2023
Same author

Toward indicators of the performance of US Infrastructures under climate change risks.

Climatic change·2021
Same author

The spectrum of cutaneous adverse events during encorafenib and binimetinib treatment in B-rapidly accelerated fibrosarcoma-mutated advanced melanoma.

Journal of the European Academy of Dermatology and Venereology : JEADV·2018
Same author

Continued Validation of Ultrasound Guidance Targeting Tasks: Assessment of Internal Structure.

Academic radiology·2018
Same author

Early clinical experience with water-jet dissection (hydro-jet) during nerve-sparing radical retropubic prostatectomy.

Minimally invasive therapy & allied technologies : MITAT : official journal of the Society for Minimally Invasive Therapy·2017
Same journal

Long-term recurrence and acute seizure clustering in children with convulsions with mild gastroenteritis: a systematic review and meta-analysis.

European journal of pediatrics·2026
Same journal

Cost-benefit analysis of nirsevimab for respiratory syncytial virus prevention in infants: a population-based study.

European journal of pediatrics·2026
Same journal

Consensus statement on the use of standardized early mobilization in pediatric patients admitted to pediatric intensive care units in Italy.

European journal of pediatrics·2026
Same journal

Ultrasound-guided midline catheters in the neonatal intensive care unit: a single-center pilot study.

European journal of pediatrics·2026
Same journal

Gastrointestinal pathogens in paediatric patients with diarrhoea during the COVID-19 pandemic in Spain: a multicentre molecular-based prospective study.

European journal of pediatrics·2026
Same journal

Low serum immunoglobulin levels in pediatric atopic dermatitis: association with disease severity and exploratory scores.

European journal of pediatrics·2026
See all related articles

Primary hyperoxaluria type 2 (PH2) is a rare genetic disorder causing kidney stones and calcifications. Early diagnosis and management are crucial as renal prognosis may be worse than previously thought.

Area of Science:

  • Nephrology
  • Medical Genetics

Background:

  • Primary hyperoxaluria type 2 (PH2) is a rare metabolic disorder.
  • Characterized by D-glycerate dehydrogenase/glyoxylate reductase deficiency.
  • Leads to hyperoxaluria and L-glycerate excretion, key diagnostic markers.

Purpose of the Study:

  • To highlight the importance of considering PH2 in patients with hyperoxaluria-related urolithiasis or nephrocalcinosis.
  • To emphasize the need for specific therapeutic strategies to improve renal survival.
  • To alert clinicians about the potential for worse renal prognosis than previously anticipated.

Main Methods:

  • Literature review of reported PH2 cases.
  • Analysis of metabolic defects and clinical manifestations.
  • Evaluation of therapeutic approaches and renal transplantation outcomes.

Related Experiment Videos

Main Results:

  • PH2 is diagnosed by hyperoxaluria and L-glycerate excretion.
  • Therapeutic measures include reducing urinary calcium oxalate saturation with potassium citrate or pyrophosphate.
  • Isolated renal transplantation in end-stage renal failure carries a high risk of recurrence.

Conclusions:

  • PH2 is an important, albeit rare, cause of urolithiasis and nephrocalcinosis.
  • Long-term follow-up is essential due to potentially underestimated renal prognosis.
  • Preventing secondary complications and optimizing treatment are vital for renal survival.