[The mechanisms of the stimulating effect of tissue basophils on the reparative processes in inflammation]

Mast cells stimulating effect on reparative processes in inflammation involves histamine, serotonin and heparin. This was shown on the model of E. coli-induced acute infectious peritonitis in rats using antagonists of major biologically active mast cells products (histamine, serotonin and heparin)-dimedrole, cimetidine, ciproheptadine and protamine sulfate. Fibroblast accumulation is associated with histamine, influencing predominantly H1- and H2-receptors as well as with serotonin. Fibroblast proliferative synthetic ability increases through histamine action on H1-receptors and serotonin and heparin influence. Accumulation of monocytes-macrophages and their proliferative synthetic ability stimulation is affected by histamine (through H1-receptors) and serotonin.