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Natural occurrence of 2'-phospho-cyclic ADP ribose in mammalian tissues
C Q Vu1, D L Coyle, M K Jacobson
1Division of Medicinal Chemistry and Pharmaceutics, College of Pharmacy, University of Kentucky, Lexington 40536, USA.
Biochemical and Biophysical Research Communications
|July 30, 1997
Abstract:
2'-Phospho-cyclic ADP-ribose (P-cADPR) is a newly identified Ca2+-mobilizing agent derived from NADP that stimulates intracellular Ca2+ release by a mechanism distinct from inositol 1, 4, 5-trisphosphate. In this report, we show that P-cADPR is an endogenous metabolite in bovine tissues with basal levels ranging from 17.6 to 89.5 fmol/mg protein. The natural occurrence of this Ca2+-mobilizing nucleotide provides a potential link between NADP(H) metabolism and regulation of Ca2+ homeostasis.