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MnDPDP-enhanced MR imaging of the liver. Correlation with surgical findings
P A Kane1, V Ayton, H L Walters
1Department of Radiology, Kings College Hospital, London, UK.
Purpose:
To compare lesion detection and characterisation predicted by MnDPDP-enhanced MR imaging with surgical excision and pathological examination.
Material And Methods:
Ninety patients were intravenously infused at a rate of 2 to 3 ml/min with 5 mumol/kg mangafodipir trisodium (MnDPDP, Teslascan). The patients were examined with spin-echo and gradient-echo T1-weighted MR imaging at 1 h and 24 h after the end of infusion. The results were compared with identical pre-contrast sequences. In 20 of these patients, the pre-operative MR findings were compared with intra-operative ultrasonography and histology of the resected liver specimens.
Results:
In those with liver metastases, there was a good correlation between MR and the hepatic disease in 11 out of 14 cases. In the group with primary liver tumours, MR findings correlated with hepatic disease in 5 out of 6 cases.
Conclusion:
Liver lesion characterisation is possible with MnDPDP, and MR contrast enhancement with this agent is considered to be an important adjunct to the radiological assessment of patients with neoplastic liver disease where accurate decisions for surgical planning are imperative.
Insights
Mangafodipir trisodium (MnDPDP) enhanced MR imaging accurately detects and characterizes liver lesions. This method correlates well with surgical and pathological findings, aiding in surgical planning for neoplastic liver disease.
Area of Science:
- Radiology
- Medical Imaging
- Hepatology
Background:
- Accurate characterization of liver lesions is crucial for effective surgical planning.
- Magnetic Resonance Imaging (MRI) is a key modality for liver lesion assessment.
- Novel contrast agents can potentially improve MRI diagnostic performance.
Purpose of the Study:
- To evaluate the efficacy of mangafodipir trisodium (MnDPDP)-enhanced MRI in detecting and characterizing liver lesions.
- To compare MnDPDP-enhanced MRI findings with surgical excision and pathological examination.
- To assess the diagnostic accuracy of MnDPDP-enhanced MRI for neoplastic liver disease.
Main Methods:
- Ninety patients received intravenous MnDPDP (5 mumol/kg).
- T1-weighted spin-echo and gradient-echo MRI were performed at 1 and 24 hours post-infusion.
- Pre-operative MRI findings were compared with intra-operative ultrasonography and histology in 20 patients.
Main Results:
- A good correlation between MRI and hepatic disease was observed in 11 out of 14 patients with liver metastases.
- In primary liver tumors, MR findings correlated with hepatic disease in 5 out of 6 cases.
- MnDPDP-enhanced MRI demonstrated high accuracy in lesion detection and characterization.
Conclusions:
- MnDPDP-enhanced MRI enables accurate liver lesion characterization.
- MR contrast enhancement with MnDPDP is a valuable adjunct for radiological assessment.
- This technique supports informed surgical planning in patients with neoplastic liver disease.