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PI SZ phenotype in chronic obstructive pulmonary disease
L Alvarez-Granda1, M J Cabero-Perez, A Bustamante-Ruiz
1Department of Paediatrics, University Hospital of Valdecilia, Santander, Spain.
Thorax
|July 1, 1997
Summary
The PI Z phenotype is linked to an increased risk of developing chronic obstructive pulmonary disease (COPD). However, the PI SZ phenotype does not appear to predispose individuals to COPD.
Area of Science:
- Pulmonary Medicine
- Genetics
- Biochemistry
Background:
- Investigating the association between protease inhibitor phenotypes and chronic obstructive pulmonary disease (COPD).
- Focus on the PI SZ and PI Z phenotypes within the protease inhibitor system.
Purpose of the Study:
- To determine if the PI SZ phenotype predisposes individuals to chronic obstructive pulmonary disease (COPD).
- To clarify the role of protease inhibitor phenotypes in COPD development.
Main Methods:
- Screening of 702 COPD patients and 15,400 newborns for PI Z and PI SZ phenotypes.
- Utilized electro-immunodiffusion and isoelectric focusing for phenotype detection and confirmation.
Main Results:
- Prevalence of PI Z phenotype was significantly higher in COPD patients (0.85%) compared to newborns (0.052%).
- Prevalence of PI SZ phenotype showed no significant difference between COPD patients (0.14%) and newborns (0.156%).
Conclusions:
- The PI Z phenotype is confirmed as a predisposing factor for COPD development.
- The PI SZ phenotype does not show an increased risk for developing COPD.