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Influence of the adenovirus 5 E1A oncogene on chromatin remodelling
1Department of Microbiology and University of Virginia Cancer Center, School of Medicine, University of Virginia, Charlottesville 22908, USA. jmymryk@julian.uwo.ca
Abstract:
In the eukaryotic nucleus, compaction of DNA into chromatin can limit the access of trans-acting factors, providing an additional level of regulation to processes such as transcription, replication, and repair. Recent studies have suggested that the protein products of the adenovirus 5 E1A oncogene can influence SWI-SNF and histone acetylase activities, two cellular processes that facilitate transcription in the context of chromatin. This review focuses on the unexpected effects of E1A on cellular processes that remodel chromatin in relation to its transcriptional and transforming activities.
Insights
Adenovirus E1A oncogene proteins unexpectedly impact cellular chromatin remodeling. This influences transcription, replication, and repair, affecting cell transformation.
Area of Science:
- Molecular Biology
- Epigenetics
- Virology
Background:
- DNA in eukaryotic cells is compacted into chromatin, regulating access for essential cellular processes.
- Chromatin remodeling involves SWI-SNF and histone acetylase activities, crucial for transcription.
- Adenovirus 5 E1A oncogene products are implicated in influencing these cellular processes.
Purpose of the Study:
- To review the unexpected effects of Adenovirus 5 E1A on cellular chromatin remodeling.
- To explore the relationship between E1A's influence on chromatin and its transcriptional and transforming activities.
Main Methods:
- This review synthesizes findings from recent studies.
- Analysis of literature on E1A protein interactions with cellular chromatin-modifying machinery.
Main Results:
- Adenovirus E1A influences SWI-SNF and histone acetylase activities.
- These effects are linked to E1A's role in transcriptional regulation.
- E1A's impact on chromatin remodeling contributes to its transforming capabilities.
Conclusions:
- Adenovirus E1A oncogene proteins play a significant role in modulating cellular chromatin structure.
- Understanding E1A's interaction with chromatin remodeling pathways is key to comprehending viral oncogenesis and cellular transformation.