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Synaptic plasticity in hippocampal interneurons? A commentary

C J McBain1, G Maccaferri

  • 1Laboratory of Cellular and Molecular Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health (NICHD-NIH), Bethesda, MD 20892-4495, USA.

Canadian Journal of Physiology and Pharmacology
|May 1, 1997
PubMed
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Investigating synaptic plasticity in hippocampal inhibitory interneurons is complex. Current research lacks consensus due to experimental limitations in distinguishing plasticity in interneurons versus principal cells.

Area of Science:

  • Neuroscience
  • Synaptic Plasticity
  • Hippocampal Circuitry

Background:

  • Excitatory synapses onto hippocampal inhibitory interneurons are a focus of plasticity research.
  • A lack of consensus exists regarding long-term potentiation and depression in nonpyramidal neurons.

Purpose of the Study:

  • To discuss the challenges in studying synaptic plasticity in hippocampal interneurons.
  • To address technical considerations for unequivocally determining plasticity in these cells.

Main Methods:

  • Review and commentary on existing experimental paradigms.
  • Analysis of limitations in protocols used to induce synaptic plasticity.
  • Discussion of methods to separate plasticity in interneurons from principal cells.

Related Experiment Videos

Main Results:

  • Existing experimental designs often confound plasticity in interneurons with that in principal cells.
  • Disagreement on interneuron plasticity stems from methodological challenges.

Conclusions:

  • Further refinement of experimental approaches is necessary.
  • Clearer methodologies are required to resolve the debate on long-term potentiation and depression in hippocampal interneurons.