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Updated: Aug 13, 2026

Detection of Protein S-Acylation using Acyl-Resin Assisted Capture
Published on: April 10, 2020
Fatty acid acylation of platelet proteins
E M Van Cott1, L Muszbek, M Laposata
1Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114-2696, USA.
Abstract:
A variety of fatty acids can become covalently attached to platelet proteins by thioester linkage. These fatty acids include palmitate, myristate, stearate, arachidonate, and eicosapentaenoate. More than 20 platelet proteins can be acylated by fatty acids. Several of the acylated platelet proteins have been identified, including glycoprotein Ib beta, glycoprotein IX, P-selectin, G-protein alpha subunits, and CD9. This report reviews the fatty acid acylation of platelet proteins.
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