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The "cold hands sign" in multiple system atrophy

C Klein1, R Brown, G Wenning

  • 1University Department of Clinical Neurology, Institute of Neurology, London, England.

Movement Disorders : Official Journal of the Movement Disorder Society
|July 1, 1997
PubMed
Summary
This summary is machine-generated.

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Patients with multiple system atrophy (MSA) exhibit significantly lower hand skin temperatures compared to Parkinson's disease patients and healthy individuals. This "cold hands sign" may indicate neurovascular dysfunction and aid in early MSA detection.

Area of Science:

  • Neurology
  • Vascular Biology
  • Clinical Medicine

Background:

  • Patients with multiple system atrophy (MSA) frequently present with cold, discolored hands and impaired circulation.
  • These symptoms suggest potential neurovascular dysregulation affecting the extremities.

Purpose of the Study:

  • To compare hand skin temperature between patients with probable MSA, idiopathic Parkinson's disease (PD), and healthy controls.
  • To investigate the impact of a standard cooling procedure on hand skin temperature in these groups.

Main Methods:

  • Hand skin temperature was measured in nine MSA patients, ten PD patients, and ten healthy controls.
  • Measurements were taken at rest and after a standardized cooling protocol.
  • Skin color changes and temperature recovery times were also observed.

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Main Results:

  • The MSA group exhibited significantly lower baseline hand skin temperature than both PD and control groups.
  • MSA patients showed a greater reduction in skin temperature after cooling compared to PD patients.
  • While recovery rates were similar, MSA patients took longer to return to baseline temperatures.

Conclusions:

  • Lower hand skin temperature, particularly after cooling, is a notable characteristic of MSA.
  • The "cold hands sign" may serve as a valuable clinical indicator for raising suspicion of MSA.
  • These findings highlight a potential neurovascular defect in the distal extremities of MSA patients.