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Cisapride poisoning
R L Gibly1, F G Walter, J Kloster
1Department of Surgery, University of Arizona Health Sciences Center, Tucson 85724-5057, USA.
Veterinary and Human Toxicology
|August 1, 1997
Abstract:
A MEDLINE search from 1966-1996 revealed no reports of cisapride poisoning. An 8-mo-old, 8.9 kg girl received 8 mL of cisapride (Propulsid Suspension, 1 mg/mL, Janssen Pharmaceutica, Titusville, NJ) rather than the usual dose of 0.8 mL, resulting in an inadvertent, 10-fold, iatrogenic, dosing error. She developed emesis, hyperactive bowel sounds, abnormal behavior, mild hyperthermia, tachycardia, hypertension, and thrombocytosis. This is the first published report of poisoning with cisapride.