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Updated: Sep 26, 2026

Application of MassSQUIRM for Quantitative Measurements of Lysine Demethylase Activity
Published on: March 11, 2012
Gas chromatographic/mass spectrometric determination of lysergic acid diethylamide (LSD) in serum samples
1Institute of Legal Medicine, Rheinische Friedrich-Wilhelms-University, Bonn, Germany.
Abstract:
A sensitive method for the detection and quantification of lysergic acid diethylamide (LSD) in serum samples is described. After liquid-liquid extraction the trimethylsilyl derivative of LSD is detected by gas chromatography-mass spectrometry. Experiments with spiked samples resulted in a recovery of 76%, the coefficient of variation was 9.3%. Excellent linearity was obtained over the range 0.1-10 ng ml-1. Additionally experiments demonstrating the light sensitivity of LSD are presented together with casuistics.
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