Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The L-AP4 receptor

C Thomsen1

  • 1Novo Nordisk A/S, Health Care Discovery, Måløv, Denmark. CHT@NOVO.DK

General Pharmacology
|August 1, 1997
PubMed
Summary
This summary is machine-generated.

The L-2-amino-4-phosphonobutyric acid (L-AP4) receptor, crucial for synaptic transmission, is not a single entity. Research suggests it may involve multiple metabotropic glutamate receptor (mGluR) subtypes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chemical exposome patterns in mothers and children across urbanisation levels in five European birth cohorts.

Journal of exposure science & environmental epidemiology·2026
Same author

Comparison of aggregated exposure to perfluorooctanoic acid (PFOA) from diet and personal care products with concentrations in blood using a PBPK model - Results from the Norwegian biomonitoring study in EuroMix.

Environmental research·2023
Same author

Approaches to mixture risk assessment of PFASs in the European population based on human hazard and biomonitoring data.

International journal of hygiene and environmental health·2022
Same author

PFAS levels and determinants of variability in exposure in European teenagers - Results from the HBM4EU aligned studies (2014-2021).

International journal of hygiene and environmental health·2022
Same author

Comparison of aggregated exposure to di(2-ethylhexyl) phthalate from diet and personal care products with urinary concentrations of metabolites using a PBPK model - Results from the Norwegian biomonitoring study in EuroMix.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2020
Same author

Structural brain maturation differs between preterm and term piglets, whereas brain activity does not.

Acta paediatrica (Oslo, Norway : 1992)·2018
Same journal

Endothelium-dependent vasorelaxant and antiproliferative effects of apigenin.

General pharmacology·2002
Same journal

Reversal of hypercapnia induces endothelin-dependent constriction of basilar artery in rabbits with acute metabolic alkalosis.

General pharmacology·2002
Same journal

Reversal of hypercapnia induces KATP channel and NO-independent constriction of basilar artery in rabbits with acute metabolic alkalosis.

General pharmacology·2002
Same journal

Contractile responses in spontaneously diabetic mice. II. Effect of cholestyramine on enhanced contractile response of aorta to norepinephrine in C57BL/KsJ (db/db) mice.

General pharmacology·2002
Same journal

Contractile responses in spontaneously diabetic mice. I. Involvement of superoxide anion in enhanced contractile response of aorta to norepinephrine in C57BL/KsJ(db/db) mice.

General pharmacology·2002
Same journal

Investigation of basal endothelial function in the obese Zucker rat in vitro.

General pharmacology·2002
See all related articles

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Pharmacology

Background:

  • The L-2-amino-4-phosphonobutyric acid (L-AP4) receptor was identified by its role in depressing synaptic transmission in the hippocampus and retina.
  • Its precise molecular identity remains elusive, hindering a complete understanding of its function.

Purpose of the Study:

  • To investigate the molecular identity and physiological roles of the L-AP4 receptor.
  • To explore the potential involvement of metabotropic glutamate receptor (mGluR) subtypes in L-AP4 receptor activity.

Main Methods:

  • Electrophysiological and biochemical studies were conducted to examine L-AP4 receptor physiology.
  • Pharmacological profiling of metabotropic glutamate receptors (mGluRs) was performed.

Related Experiment Videos

Main Results:

  • High-affinity targets for L-AP4 have been identified through the molecular cloning of mGluR subtypes.
  • Evidence suggests that the L-AP4 receptor is not a single molecular entity but likely involves multiple receptor subtypes.

Conclusions:

  • The L-AP4 receptor system is complex, potentially comprising several mGluR subtypes.
  • Further research into mGluR pharmacology and L-AP4 receptor physiology is needed to fully elucidate its molecular composition and function.