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Repeated administration intensifies the reinforcing effect of fencamfamine in rats
R DeLucia1, C S Planeta, M L Aizenstein
1Departamento de Farmacologia, Unviersidade de São Paulo, Brazil.
General Pharmacology
|August 1, 1997
Abstract:
1. In the present study, we evaluated the role of repeated administration on conditioning place preference (CPP) induced by fencamfamine (FCF) in male rats. 2. Repeated FCF (3.5 mg/kg) or saline once or daily for ten consecutive days enhanced sniffing duration and decreased locomotion and rearing duration. 3. At the 3.5 mg/kg dose, FCF produced a significant place-preference effect. 4. Repeated exposures to FCF intensified its reinforcing properties. 5. These results suggest that repeated FCF administration sensitizes its rewarding effects, as with other addictive substances.