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Estrogen-androgen for hormone replacement. A review
M J Rosenberg1, T D King, M C Timmons
1Health Decisions, Inc., Chapel Hill, NC 27514-2884, USA.
The Journal of Reproductive Medicine
|July 1, 1997
Summary
Estrogen-androgen replacement therapy may offer additional benefits for postmenopausal women compared to estrogen-only therapy, potentially improving bone health and well-being. However, cardiovascular effects require further investigation.
Area of Science:
- Endocrinology
- Women's Health
- Gerontology
Background:
- Postmenopausal hormone replacement therapy (HRT) is widely used.
- The role of androgens in HRT requires critical examination.
Purpose of the Study:
- To critically examine the role of androgens as part of postmenopausal hormone replacement therapy.
Main Methods:
- Systematic review of original reports and literature reviews.
- Electronic database searches and manual bibliography searches were employed.
Main Results:
- Estrogen-androgen therapy may enhance protection against osteoporosis and improve libido, energy, and well-being compared to estrogens alone.
- While estrogen-androgen replacement may reduce beneficial high-density lipoprotein increases, this could be offset by decreased triglycerides.
- Long-term cardiovascular effects of estrogen-androgen replacement remain undetermined.
Conclusions:
- Despite limited clinical trials and subjective outcome measures, available data suggest estrogen-androgen replacement may offer benefits beyond estrogen-only therapy for many postmenopausal women.