[Cases of multiple tumors in our clinic]

Between 1989 and 1994, 719 patients had been treated with tumours at the Department of Surgery, Teaching Hospital of Semmelweis University Medical School, Budapest, Multiple tumours were found in 53 cases (7.37%), 49 of these being duplex and four triplex form. In men colorectal carcinoma was the most frequent while in women synchrone and metachrone breast cancers. Simultaneous breast tumors were most often found in senior patients (mean age 72.7) and metachrone ones at younger age (first tumor at 54.8 and the second one at 65.4 years of age, the following time being 10.6 years). Colorectal and gynecological tumours appeared with breast cancer in 5 cases. Regional colorectal tumours developed in five patients after radiotreatment of the pelvis. Familiar accumulation of colorectal cancer occurred in 4 cases. Lynch syndrome developed in 2 patients. The role of genetical factors is known in this group of illness, and they need to be screened. In this study the metachrone cancer in women occurred most frequently and only these patients received oncological treatment. The more effective treatment is supposed to enhance the number of multiplex tumours in which etiological factors also can play a role likewise mutagen effects of the first cancer therapies. The importance of collecting and processing these data is to referre to those risks, which should be considered in our everyday diagnostic work and postoperative care in these groups of patients.