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Hemodynamic changes after complete unilateral ureteral obstruction in the young lamb
K M Kim1, G A Bogaert, H T Nguyen
1Department of Urology, Seoul National University Children's Hospital, Korea.
The Journal of Urology
|September 1, 1997
Summary
Renal blood flow in young lambs with ureteral obstruction is preserved, unlike previous findings. This study reveals unique hemodynamic responses in immature kidneys to urinary tract obstruction.
Area of Science:
- Pediatric Nephrology
- Renal Physiology
- Urology
Background:
- Acute unilateral ureteral obstruction is a common pediatric urologic emergency.
- Understanding renal hemodynamic responses is crucial for managing obstruction.
- Previous studies in adult models show increased renal blood flow post-obstruction.
Purpose of the Study:
- To investigate renal hemodynamic changes in response to complete acute unilateral ureteral obstruction in young lambs.
- To compare these responses to those previously reported in other models.
Main Methods:
- Seven 4-week-old lambs underwent unilateral ureteral obstruction.
- Renal blood flow was measured using ultrasonic flow transducers.
- Ureteral and arterial blood pressure were continuously monitored.
Main Results:
- Obstructed kidney: Renal blood flow remained stable for 5 hours, then decreased to 71% of baseline by day 5.
- Contralateral kidney: Renal blood flow mirrored the obstructed kidney but with a smaller increase (122% at 5 days).
- Mean ureteral pressure significantly increased post-obstruction, then gradually decreased but remained elevated.
Conclusions:
- Young lamb renal response to obstruction differs from prior reports.
- Renal blood flow is preserved and does not increase after obstruction in this model.
- Possible factors include sheep kidney anatomy, vascular immaturity, or spontaneous decompression mechanisms.