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Implication of cyclin D1 in malignant lymphoma
M Callanan1, D Leroux, J P Magaud
1Laboratoire GRL, Institut Albert Bonniot, La Tronche, France.
Critical Reviews in Oncogenesis
|January 1, 1996
Summary
The t(11;14) chromosomal translocation activates the CCND1 gene, leading to cyclin D1 overexpression. This is a key driver in mantle cell lymphoma and other lymphoid malignancies.
Area of Science:
- Oncology
- Genetics
- Cell Biology
Background:
- The chromosomal translocation t(11;14)(q13;q32) is a hallmark of certain lymphoid malignancies.
- This translocation is particularly prevalent in mantle cell lymphoma (MCL), occurring in up to 70% of cases.
- The translocation involves juxtaposing IGH sequences with the BCL1/PRAD1 region at 11q13.
Purpose of the Study:
- To review the role of cyclin D1 in cell cycle regulation.
- To discuss the mechanisms and pathogenetic impact of cyclin D1 activation in lymphoproliferative disorders.
- To review diagnostic strategies for CCND1 rearrangement/overexpression, especially in MCL.
Main Methods:
- Molecular analysis to identify the gene at 11q13.
- Review of existing literature on cyclin D1 function and its role in lymphoproliferative disorders.
- Examination of diagnostic approaches for CCND1 alterations.
Main Results:
- The BCL1 gene, now known as CCND1, encodes cyclin D1, a critical regulator of the G1/S cell cycle transition.
- Cyclin D1 overexpression is a common finding in MCL and other malignancies with 11q13 rearrangement.
- CCND1 is confirmed as the gene targeted by these rearrangements.
Conclusions:
- CCND1 activation through translocation is a key pathogenetic event in MCL.
- Understanding cyclin D1's role is crucial for diagnosing and potentially treating these cancers.
- Effective diagnostic strategies are available for detecting CCND1 rearrangement and overexpression.