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A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis
18:11

A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis

Published on: December 28, 2012

[Sudden death in myocardial infarct, its precursors and the problems of prevention]

N A Mazur, O S Riabokon'

    Kardiologiia
    |December 1, 1979
    PubMed

    Insights

    Continuous ECG monitoring detected ventricular extrasystoles in most myocardial infarction patients. Antiarrhythmic drugs like lipocaine and trimecaine significantly reduced complex extrasystoles and primary ventricular fibrillation incidence.

    Area of Science:

    • Cardiology
    • Clinical Electrophysiology

    Background:

    • Myocardial infarction frequently presents with ventricular arrhythmias.
    • Ventricular extrasystoles are recognized precursors to life-threatening ventricular fibrillation.
    • Early detection and management of these arrhythmias are crucial for patient outcomes.

    Purpose of the Study:

    • To assess the utility of continuous ECG monitoring for detecting ventricular extrasystoles in myocardial infarction patients.
    • To evaluate the efficacy of lipocaine and trimecaine in reducing complex ventricular extrasystoles and preventing ventricular fibrillation.

    Main Methods:

    • Continuous magnetic tape electrocardiogram (ECG) recordings were utilized.
    • Patients with uncomplicated myocardial infarction were monitored for ventricular extrasystoles.
    • A randomized controlled trial compared antiarrhythmic drug treatment (lipocaine or trimecaine) with a control group.

    Main Results:

    • Continuous ECG revealed ventricular extrasystoles in 99% of myocardial infarction patients.
    • 95% of patients exhibited extrasystoles considered precursors to ventricular fibrillation.
    • Antiarrhythmic drug treatment significantly decreased complex ventricular extrasystoles compared to the control group.
    • Ventricular fibrillation occurred in 3 patients receiving treatment versus 8 in the control group.

    Conclusions:

    • Continuous ECG monitoring is highly effective for detecting ventricular arrhythmias post-myocardial infarction.
    • Lipocaine and trimecaine demonstrate antiarrhythmic properties, reducing the progression to complex arrhythmias and ventricular fibrillation.

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