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Transjugular liver biopsy. An experience based on 500 procedures
R Brenard1, Y Horsmans, J Rahier
1Service d'Hépato-Gastroentérologie, Cliniques Universitaires St Luc, UCL, Bruxelles.
Acta Gastro-Enterologica Belgica
|April 1, 1997
Summary
Transjugular liver biopsy is a safe and effective procedure for obtaining adequate liver tissue, even in high-risk patients. Specimen adequacy was high, though larger specimens correlated with increased hepatic venous pressure gradient.
Area of Science:
- Hepatology
- Interventional Radiology
- Gastroenterology
Background:
- Transjugular liver biopsy is a crucial diagnostic tool.
- It constitutes a significant portion of liver biopsies performed in specialized units.
- Assessing its safety and efficacy in a large cohort is important.
Purpose of the Study:
- To evaluate the safety and efficacy of transjugular liver biopsy.
- To determine the adequacy of liver specimens obtained.
- To explore factors influencing specimen size and biopsy success.
Main Methods:
- Retrospective analysis of 500 transjugular liver biopsies.
- Assessment of specimen adequacy for liver architecture evaluation.
- Correlation analysis between specimen size and hepatic venous pressure gradient.
Main Results:
- The procedure was safe, even in high-risk patients.
- Adequate liver specimens were obtained in 87.6% of cases (minimum core size 7.6 mm).
- Specimen size negatively correlated with hepatic venous pressure gradient (p < 0.0001); 3.6% unsuccessful biopsies and 3.4% asymptomatic perforations.
Conclusions:
- Transjugular liver biopsy is a safe and effective procedure with high specimen adequacy.
- It is a valuable alternative, especially for high-risk patients.
- Understanding factors affecting specimen size is crucial for optimal diagnostic yield.