Assessment of ischemic changes by ambulatory ECG-monitoring: comparison with 12-lead ECG during exercise testing

The accuracy of commercially available ambulatory electrocardiographic monitoring (AEM) systems for reproducing ischemic changes has been questioned. Since these systems are widely used for evaluation of ST-segment changes, both for prognostic purposes and for assessment of the efficacy of antiischemic drugs, such doubts must be clarified. For this purpose, we recorded electrocardiograms (ECGs) during exercise testing, using split leads, simultaneously with a 12-lead electrocardiograph and with the Marquette AEM recorder. We studied 29 patients with proven coronary artery disease and positive exercise tests and 19 individuals with low likelihood of coronary artery disease and negative stress tests. All 29 patients who had ST-segment depression during exercise as recorded on the 12-lead ECG had ST-segment depression in at least one of the three AEM leads (resembling the V5, V3, and aVF leads of the 12-lead system). The maximal degree of ST-segment depression with AEM was similar to 12-lead ECG (2.3 mm and 2.1 mm, respectively). The best lead for ischemia detection with AEM was the V5 type, which detected ischemic changes in 26 of the 29 patients, while the 12-lead V5 detected ischemia in 24 patients. The inferior AEM lead detected ischemia in only 4 patients, while the aVF lead of the 12-lead ECG detected ischemia in 23 patients. Of the 19 patients with negative exercise tests only 1 patient had a 1-mm ST-segment depression on AEM. Thus, of the 48 patients studied, similar responses were observed in 47. The results of indicate that the Marquette AEM system is as accurate as the 12-lead ECG in detecting ischemic changes and in assessing their severity.