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Related Experiment Videos

Fear decrease in transgenic mice overexpressing bcl-2 in neurons

L Rondi-Reig1, Y Lemaigre Dubreuil, J C Martinou

  • 1Laboratoire de Neurobiologie du Développement et Institut des Neurosciences (URA CNRS 1488), Université P. et M. Curie, Paris, France.

Neuroreport
|July 28, 1997
PubMed
Summary
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Neuronal destruction or BCL-2 gene overexpression in specific brain areas reduces anxiety and neophobia. This suggests that both fewer and more neurons in these regions can decrease fear-related behaviors.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Behavioral Genetics

Background:

  • Neuronal destruction in the amygdala, hypothalamus, and cerebellum decreases anxiety and neophobia.
  • The human bcl-2 gene, when overexpressed in transgenic mice (Hu-bcl-2), reduces natural neuronal death, increasing neuron count and brain size.

Purpose of the Study:

  • To investigate the fear-related behavior of Hu-bcl-2 transgenic mice.
  • To compare the effects of neuronal destruction versus BCL-2 overexpression on anxiety and neophobia.

Main Methods:

  • Utilizing Hu-bcl-2 transgenic mice with neuron-specific enolase promoter-driven BCL-2 expression.
  • Assessing fear-related behaviors, specifically anxiety and neophobia, in these mice.

Main Results:

Related Experiment Videos

  • Hu-bcl-2 transgenic mice exhibited reduced anxiety and neophobia.
  • The study observed that an increased number of neurons (due to BCL-2 overexpression) produced similar behavioral modifications as neuronal destruction.

Conclusions:

  • Supernumerary neurons, similar to neuronal destruction, can lead to a diminution in anxiety and neophobia.
  • These findings highlight the complex relationship between neuronal number and fear-related behaviors in specific brain regions.